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These results were very nearly completely inhibited by fulvestrant, an estrogen receptor blocker, into the level that fulvestrant had comparable metabolic problems to that of ovariectomization. In conclusion, estrogen replacement treatment in OVX females substantially ameliorated the metabolic derangements of insulin resistance, dyslipidemia and hepatic fat accumulation possibly via corrections of hepatic phrase of miR-33 and miR-34a; effects which were mediated through the r
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