https://cgrpreceptor.com/the-r....eason-why-expectatio
Septins tend to be increasingly recognized as book cytoskeletal elements, but details on their particular legislation and contribution to migration are lacking. Right here, we show that the septin regulator Cdc42EP5 is regularly required for amoeboid melanoma cells to occupy and migrate into collagen-rich matrices and locally invade and disseminate in vivo. Cdc42EP5 associates with actin structures, resulting in increased actomyosin contractility and amoeboid migration. Cdc42EP5 affects these function
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