https://www.selleckchem.com/pr....oducts/as1517499.htm
The signal from a baseline compendium was obscured when the number of added sources of variability was small. Applying statistical correction methods rescued the underlying signal in these cases. However, as the number of sources of variability increased, it became easier to detect the original signal even without correction. In fact, statistical correction reduced our power to detect the underlying signal. When combining a modest number of experiments, it is best to correct for experiment-specific noise. However, when many experiment
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