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05). Over time, a decrease in osteoprotegerin and Interleukin-1β concentrations in PICF along with an increase in receptor activator of unclear factor kappa-B ligand, periostin and peroxidasin gene expressions in peri-implant mucosa were noted within both groups (P less then 0.05) without significant intergroup differences. Conclusion Within the limits, implants with PS design rendered significant benefits over PM design in PD and mSBI reduction during a 6-week healing. However, molecular changes within PICF and peri-implant mucosa as
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