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4%) than in those with TV ≥50% (3.2%). Furthermore, only TVDT less then 5 years was significantly associated with LN metastasis (p = 0.002). In univariate and multivariate analyses, TVDT less then 5 years was an independent risk factor for disease progression with respect to new development of LN metastasis (hazard ratio [HR] = 6.51, CI 1.73-24.50; p = 0.002) and tumor enlargement (HR = 20.89, CI 5.78-75.48; p less then 0.001). Finally, 86 (22.6%) patients underwent delayed surgery, and the most common reason was patient anxiety. Conc
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