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a significantly improved OS as compared to patients with PR or NR. Nodal status is the most important pathologic prognostic factor. Neoadjuvant chemoradiation may be an important driver of pathologic response. Copyright © 2020 Wittmann, Hall, Christians, Barnes, Jariwalla, Aldakkak, Clarke, George, Ritch, Riese, Khan, Kulkarni, Evans, Erickson, Evans and Tsai.This perspective highlights the history and challenges of developing CD3-based bispecific T-cell engagers (TCEs) as cancer therapeutics as well as considerations and potential s
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