https://www.selleckchem.com/pr....oducts/dir-cy7-dic18
Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol ), remains limited despite growing global demands. Low yields of the critical taxadiene precursor remains a key bottleneck in microbial production. In this study, the key challenge of poor taxadiene synthase (TASY) solubility in S. cerevisiae was revealed, and the strains were strategically engineered to relieve this bottleneck. Multi-copy chromosomal integration of TASY harbouring a selection of fusion solubility tags improved taxadiene titres 2
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