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detection. In order to explore the pathophysiology underlying type 2 diabetes we examined the impact of gene variants associated with type 2 diabetes on circulating levels of glucagon during an oral glucose tolerance test (OGTT). Furthermore, we performed a genome-wide association study (GWAS) aiming to identify novel genomic loci affecting plasma glucagon levels. Plasma levels of glucagon were examined in samples obtained at three time points during an OGTT; 0, 30 and 120min, in two separate cohorts with a total of up to 1899 individuals. Cross-sectional a
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