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Recently, a lignan [(-)-(2R, 3R)-1,4-O-diferuloylsecoisolariciresinol, DFS] from Alnus japonica has been discovered to lessen the viability of colon cancer cells. In this study, we have observed DFS-induced autophagy in a number of cancer tumors mobile outlines. In addition, DFS generated ER stress, in line with the activation of unfolded protein response (UPR) transducers and an elevated phrase of UPR target genes in prostate and cancer of the colon cells. Further i
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