https://www.selleckchem.com/pr....oducts/PHA-739358(Da
A microinjection of orexin B into the vTMN potentiated incapacitation and joint edema, while coadministration of the OX1/2 receptor antagonist almorexant with orexin B did not. These data support the notion that TMN participates in the modulation of a peripheral inflammatory process by means of histaminergic projections to the spinal cord, and the hypothalamus may trigger TMN activation by means of glutamate and orexin. These data support the notion that TMN participates in the modulation of a peripheral inflammatory proc
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