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9% (2.4-32.8%), 88.4% (54.6-100%), and 84.2% (40.3-100%), respectively. Respective serum gastrin levels were 79 (75-21 pg/ml, 310 (110-87 pg/ml, and 170 (140-93 pg/ml. In cases with hypergastrinemia (gastrin ≥ 200pg/ml) induced by vonoprazan 10mg alone, concomitant treatment with pirenzepine significantly reduced serum gastrin levels from 370 to 180pg/ml (P = 0.028). Although pirenzepine does not enhance acid inhibition, it does improve hypergastrinemia induced by vonoprazan to some extent. Although pirenzepine does not enhance a
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