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Although the literature recognizes the participation of patients in medical decisions as an important indicator of quality, there is a lack of consensus regarding the influence of advance directives (ADs) on reducing aggressive measures during end-of-life care involving cancer patients. A systematic review was conducted to analyze the influence of ADs on reducing aggressive end-of-life care measures for cancer patients. We searched the Medline, Embase, Web of Science, and Lilacs databases for studies published until March 2018 using the f
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