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The advantages and weaknesses of these compounds in terms of therapeutic potential are discussed.Circulating levels of 2-hydroxybutyrate (2H are highly related to glycemic status in different metabolomic studies. According to recent evidence, 2HB is an early biomarker of the future development of dysglycemia and type 2 diabetes mellitus and may be causally related to the progression of normal subjects to impaired fasting glucose or insulin resistance. In the present study, we developed and validated a simple, specific and sensitive gas
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