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Up to now, TAM concentrating on strategies have actually centered on macrophage depletion and inhibition of the recruitment to the TME. Nevertheless, these strategies show restricted therapeutic efficacy, although trials are nevertheless underway with combo therapies. The fact that macrophages have the potential for antitumor activity has moved the TAM focusing on field toward the introduction of TAM-reprogramming strategies to guide this antitumor immune response. H
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