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201. Depletion of macrophages reversed prokineticin2-mediated protection against polymicrobial sepsis. This study elucidated a previously unrecognized role of prokineticin2 in clinical diagnosis and treatment of sepsis. The proof-of-concept study determined a central role of prokineticin2 in alleviating sepsis-induced death by regulation of macrophage function, which presents a new strategy for sepsis immunotherapy. This study elucidated a previously unrecognized role of prokineticin2 in clinical diagnosis and treatment of sepsis. The p
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