https://www.selleckchem.com/pr....oducts/gsk2830371.ht
Following such an accelerated mutagenesis-followed by selection approach, three phenotypes were successfully evolved resistance to antibiotics streptomycin and rifampicin (either individually or combined) and reversion of a synthetic uracil auxotrophy. Thus, these mutator devices could be applied to accelerate the evolution of metabolic pathways in long-term evolutionary experiments, alternating cycles of (inducible) mutagenesis coupled to selection schemes toward the desired phenotype(s).To date, few studies have examined the role o
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