https://www.selleckchem.com/pr....oducts/ly2780301.htm
These results were mainly due to reduced NRM in the autoHSCT as compared to alloHSCT.Alterations in the metabolism of iron and its accumulation in the substantia nigra pars compacta accompany the pathogenesis of Parkinson's disease (PD). Changes in iron homeostasis also occur during aging, which constitutes a PD major risk factor. As such, mitigation of iron overload via chelation strategies has been considered a plausible disease modifying approach. Iron chelation, however, is imperfect because of general undesired side effects and l
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