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The model precisely predicted plasma concentration-time profiles in customers with typical renal purpose, and moderate and moderate renal impairment; the predicted and seen AUC and Cmax during these communities were comparable. In comparison to patients with normal renal function, a 1.20-, 1.45-, and 1.59-fold boost AUC was predicted in patients with moderate, reasonable, and severe renal disability, correspondingly, suggesting dosage adjustment is certainly
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