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NEDA represents a very important option in the treatment of PD. Criticisms on their use can be overcome through a better knowledge of these molecules and of the risk factors for adverse events which allow specialists to prevent the occurrence of undesired complications and consent a tailor-based approach. Abbreviations PD Parkinson's disease, DA dopamine agonists, NEDA non-ergot dopamine agonists, ICD impulse control disorders, DAWS dopamine agonist withdrawal syndrome, CYP Cytochrome P, PK pharmacokinetic, AUC area under the curve, HRT
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