https://www.selleckchem.com/pr....oducts/Rapamycin.htm
Rational Increasing evidence indicates that the physical environment is a critical mediator of tumor behavior. Hepatocellular carcinoma (HCC) develops in an altered biomechanical environment, and increased matrix stiffness is a strong predictor of HCC development. C-X-C chemokine receptor type 4 (CXCR4) is known to trigger HCC progression. However, CXCR4 as a mediator of mechanical cues in HCC is not well characterized. Methods qRT-PCR, Western blot and IHC were used to detect the CXCR4 expression in different matrix stiffness gels. M
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