https://www.selleckchem.com/pr....oducts/CP-690550.htm
The activity of the muscle-type Torpedo nicotinic acetylcholine receptor (nAChR) is highly sensitive to lipids, but the underlying mechanisms remain poorly understood. The nAChR transmembrane α‑helix, M4, is positioned at the perimeter of each subunit in direct contact with lipids and likely plays a central role in lipid-sensing. To gain insight into the mechanisms underlying nAChR lipid-sensing, we use homology modeling, co-evolutionary analyses, site-directed mutagenesis and electrophysiology to examine the role of the α-subunit M4
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