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0125 (0.05/4) based on Bonferroni correction. FindingsDHCR7 rs12785878 TC was found to be significantly associated with an increased risk of early-onset Alzheimer's disease (EOAD) (n = 300, risk allele C, adjusted OR = 1.542, adjusted 95% CI = 1.176-2.023, p = 0.002). There was no statistical significance of the other three SNPs between the two groups. Interpretation Our results suggested that DHCR7 rs12785878 TC might be associated with an increased risk of EOAD in the Chinese population, while other polymorphisms related to vi
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