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CONCLUSIONS We successfully established a model of LPR, showing histopathological and ultrastructural changes consistent with the disease. The expression of IL-8 and VEGF may increase during the pathogenesis of LPR. OBJECTIVES The dual-microphone voice range profile (VRP) is an objective measurement of vocal frequency and intensity. Precise assessments are required to ensure correct interpretation of treatment outcome. The objective of this study was to investigate the interrater reliability of the assessment. STUDY DESIGN Prospective rep
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