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Here, we reveal that PAN-selective inhibition of PDE4, not inhibition of PDE3, triggers a time- and dose-dependent buildup of chow into the stomachs of mice provided ad libitum without altering the pets' food intake or the weight of these intestines, suggesting that PDE4 inhibition impairs gastric emptying. Certainly, PDE4 inhibition induced gastric retention in an acute type of gastric motility that traces the passage of a food bolus through the st
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