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Elastic and viscous association of lamin-B1 and lamin-A is supported by transcriptional and proteomic profiling analyses. Chromatin decondensation quantified by electron microscopy softens the nucleus unless lamin-A is expressed. A mechanical framework is provided for assessing nucleus response to applied forces in health and disease. © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH Co. KGaA, Weinheim.RNA sequencing has greatly facilitated gene expression studies but is weak in studying temporal RNA dynamics; this issue can b
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