https://tcr-signal.com/fungici....dal-efficacy-involvi
We developed a virtual assessment approach to display ~200,000 substances against the FAK FERM domain, determining 20 digital chemical probes. We performed GST pull-down assessment on these compounds, finding two hits, VS4 and VS14, with nanomolar IC50 s in disrupting HER2-FAK. We performed further evaluation, including molecular docking, immunofluorescence, phosphorylation, and cellular intrusion assays to judge the substances' biological effects. One probe, VS14, was identified with the ability to
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