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ADHD Medication - Ritalin Ritalin, a chemical called methylphenidate is effective in managing ADHD symptoms in adults. It can make you feel "up," awake, alert and full of clarity. ADHD medications work by altering two brain chemicals, dopamine and norepinephrine. The majority of ADHD medications, such as Ritalin and Concerta, are stimulants. There are also nonstimulant medications. Methylphenidate Methylphenidate is a central nervous stimulant, is the preferred drug to treat attention deficit/hyperactivity disorder (ADHD) an illness