https://www.selleckchem.com/pr....oducts/BI6727-Volase
Interestingly, Met did not modify the amount of the phospho-form of CREB (pCRE, a key factor establishing nicotine conditioning, whereas AZA increased pCREB levels. Our data suggest that nicotine-seeking behavior is partially dependent on DNA methylation occurring probably at specific gene loci, such as α7 and NMDAR1 receptor gene promoters. Overall, they suggest that Met should be considered as a potential therapeutic drug to treat nicotine addiction.Hypochlorite (ClO-) mediated by oxidative stress play an important role in
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