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6156, and UKB 0.5989; trained on EB and tested on EB 0.6565, DE 0.5407, and UKB 0.6043; trained on UKB and tested on UKB 0.6133, DE 0.5143, and EB 0.6049. This result has a direct impact on the clinical usability of PRS for risk prediction models using PRS a population effect must be kept in mind when applying risk estimation models, which are based on additional genetic information even for individuals from different European populations of the same ethnicity. This result has a direct impact on the clinical usability of PRS for risk pre
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