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Misinformation and misperceptions about COVID-19 have undermined democratic system. Partisan media are regarded as one of the culprits for facilitating the spread of misinformation. Grounded in the extended communication mediation model, this study analyzes a U.S. survey sample and examines the conditional indirect effects of partisan media use on COVID-19 related misperceptions. Findings show that using conservative and liberal media both have positive effects on misperceptions and message derogation. Conservative media use has a negat