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It was shown that PRL and MAPK14 expression was colocalized and increased significantly in the pituitary gland of estradiol-injected prolactinoma mice compared with the control mice. Knockout of MAPK14 significantly inhibited tumor overgrowth, and PRL expression was decreased in estradiol-induced mice. Furthermore, MAPK14 knockout of DRD2 MAPK14 mice significantly reduced the overgrowth of pituitary gland and PRL production and secretion compared with DRD2 mice. MAPK14 knockout using siRNA inhibited PRL production in GH3 cells. These re
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