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The purpose of the present study was to clarify the expression of ARID1A in polycystic ovary syndrome (PCOS) and its effect on ovarian granulosa cells (GCs). Serum samples were collected from PCOS patients to detect the expression of ARID1A by qRT-PCR. Then, mouse and human ovarian GCs were isolated and divided into several groups according to difference in transfection, and the following experiments were performed MTT assay, flow cytometry, qRT-PCR, radioimmunoassay, and Western blotting. ARID1A was down-regulated in the serum of PCOS pa
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