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BACKGROUND AND PURPOSE To assess the frequency of plateaus in Amyotrophic Lateral Sclerosis (ALS) progression using a large population-based cohort. METHODS Data from the Piemonte and Valle d'Aosta ALS register (PARALS) were used. Patients who were diagnosed between 2007 and 2014 were considered. Follow-up period was extended until 31st December 2018. Visits after tracheostomy were excluded. A plateau was defined as a stable ALSFRS revised score lasting at least 6, 12 or 18 months. RESULTS Out of 1214 patients, 200 (16.5%), 93 (7.7%) a
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