https://www.selleckchem.com/pr....oducts/crenolanib-cp
The results obtained shown that plasma of NAFLD patients was able to reduce cell viability and mitochondrial membrane potential by about 48 and 24% (p less then 0.05), and to increase H2O2, mitochondrial ROS, and triglycerides content by about 42, 19, and 16% (p less then 0.05), respectively. An increased expression of SREBP-1c, PPARγ, NF-kB and NOX2 of about 51, 121, 63, and 46%, respectively, was observed (p less then 0.05), as well. Those effects were reduced by the use of MCC950. Thus, in hepatocytes, exposure to plasma
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