https://www.selleckchem.com/pr....oducts/cid-1067700.h
pncRNA-D is an irradiation-induced 602-nt-long long noncoding RNA (lncRNA) transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D and RNA-binding protein TLS/FUS. Since the pncRNA-D--TLS interaction is essential for pncRNA-D-stimulated CCND1 inhibition, here we studied the possible role of RNA modification in this interaction in HeLa cells. We found that osmotic stress induces pncRNA-D by recruiting RNA polymerase II to its promoter. pnc
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