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However, this classic view happens to be reviewed throughout the last 2 decades. Although O2 is essential for life, higher organisms such mammals are unable to biosynthesize molecular O2 in the body. Due to the fact several body organs of greater organisms are constantly exposed to the possibility of "O2 deficiency," living organisms have evolved elaborate methods to react to hypoxia. In this review, I will describe the system that governs oxygen homeostasis in th
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