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How many puppies homozygous and heterozygous for the insertion declined rapidly after the initial many years of genotyping, documenting the benefit of a DNA screening system in a breed with a tiny gene pool. In summary, a causative NAGLU variation in Schipperke dogs with MPS IIIB had been identified and was available at high-frequency in the type. Through genotyping and well-informed breeding practices, the prevalence of canine MPS IIIB is significantly reduced in the Schipperke populace worldwide.An
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