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84, -range ⩽0.001-0.05). EDSS = 4.0 was mainly predicted by cerebellar and cord atrophy, frontal and sensorimotor CTh and cord lesion number (OOB accuracy = 0.84, -range ⩽0.001-0.04). Cervical cord CSA ( = 0.001) and cord lesion number ( = 0.003) predicted EDSS = 6.0 (OOB accuracy = 0.77). Brain lesion burden, cortical and thalamic atrophy were the main determinants of EDSS = 3.0 and 4.0, while cord damage played a major contribution to EDSS = 6.0. Brain lesion burden, cortical and thalamic atrophy were the main determinants of EDSS = 3.0 a
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