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Hence, HA and HA/SPG products were produced and scanning electron microscopy (SEM) analysis was done to characterize the examples. Additionally, to be able to evaluate the in vivo structure reaction, samples had been implanted into a tibial bone tissue problem in rats. Histopathological, immunohistochemistry, and biomechanical analyses had been done after 2 and 6 months of implantation to investigate the results of this material on bone fix. The histological analysis demonstra
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