https://www.selleckchem.com/pr....oducts/sch-527123.ht
We examined age-associated changes in bladder and urethral coordination involving the nitric oxide (NO)/soluble guanylyl cyclase (sGC) system, which induces urethral smooth muscle relaxation, and urethral ischemic/oxidative stress changes in rats. Sixteen female Sprague-Dawley rats were divided into young (3months old) and middle-aged (12-15months old) groups. Urethral activity was evaluated by simultaneously recording intravesical pressure under isovolumetric conditions and urethral perfusion pressure (UPP) under urethane anesthesia
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