https://www.selleckchem.com/products/LBH-589.html
In contrast, treatment of washed platelets with other GPVI ligands, collagen and collagen-related peptide (CRP) caused αIIbβ3-dependent platelet aggregation and GPVI release but did not increase constitutive ADAM10 activity. Thus, fibrin engages GPVI in a manner that differs from other GPVI ligands. Inclusion of polyanionic molecules disrupted fibrin-induced platelet aggregate formation and sGPVI release, suggesting that electrostatic charge may play a role in fibrin/GPVI engagement. It may be feasible to exploit this property and speci
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