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e also activated in premalignant adenomas. Furthermore, MMP-7, MMP-9, TIMP-1 and TIMP-2 may have a potential prognostic impact in CRC. The outbreak of coronavirus disease 19 (COVID-19) has led to measures of social distancing and quarantine worldwide. This stressful period may lead to psychological problems, including increases in substance use. To investigate changes in alcohol, tobacco, and cannabis consumption before and during COVID-19 lockdown and motives for these changes in substance use. A web-based survey was filled out by an un
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