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The results of the CD technique demonstrated that the levels of the alpha-helix structure were significantly reduced when Hb was simultaneously treated with DOX and Glc. Thermal stability studies revealed that the melting temperature of Hb increased in the presence of Glc alone. However, the thermal stability of Hb decreased in the presence of Glc/DOX (combined). Since the concentration of Glc in diabetic patients is significantly higher than in healthy individuals, the toxic effects of DOX, due to its interaction with Hb, may be differ
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