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Biologic approaches targeting Type 2 cytokines are growing as possible healing choices. Here, we summarize the up-to-date evidence of pathophysiologic components and diagnosis/management ways to the patients with NERD with its phenotypic classification.Colistin has already been regarded as the very last line of defense against Gram-negative microbial infection, but, the potential nephrotoxicity restricted its clinical usage. 7-Hydroxycoumarin (7-HC) possess
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