https://www.selleckchem.com/pr....oducts/Tranilast.htm
One grade 5 and one grade 4 cardiac event occurred, both during chemoradiation and before receiving 50Gy. The 3-year OS was 48.6% (95% CI 32.5 to 72.2%) and PFS was 28.5% (95% CI 14.6 to 55.5%). Half developed distant failure with LRR occurring in 10 patients (38%), isolated in 5 patients. While feasibility was demonstrated, toxicity and compliance remained limiting factors with outcomes similar to historical controls. There remains an uncertain role for dose escalation in definitive management of locally advanced esophageal cancer. W
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