https://www.selleckchem.com/pr....oducts/h-cys-trt-oh.
FINDINGS LVNC myocardial tissues feature strongly elevated expression of SORBS2, microtubule densification and redistribution of Junctophilin 2 (JP2). SORBS2 interacts with β-tubulin, promoting its polymerization in 293T cells and hESC-derived CMs. In vivo, cardiac dysfunction, β-tubulin densification, JP2 translocation, T-tubule disorganization and Ca2+ handling dysfunction were observed in mice overexpressing SORBS2. INTERPRETATION We identified a novel mechanism through which SORBS2 interacts with β-tubulin and promotes microtub
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