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etween FM/FFM and myostatin and a negative correlation between FM/FFM and irisin (r = 0.303, P = .004 vs. r = -0.491, P less then .001). Irisin remained an important predictor of SO, even after adjusting for confounding variables (OR1.105; 95% CI0.965-1.338, P = .002). The optimal cut-off value for irisin to predict SO was 9.49 ng/mL (specificity = 78.1%, sensitivity = 75.8%). In addition, A1c was an independent risk factor for SO development (OR1.358, P = .055).This study showed that low irisin levels ( less then 9.49ng/mL) and poor g
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