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Introduction In a subset of chronic obstructive pulmonary disease (COPD)patients the course of the disease is complicated by a severe acute exacerbations (AECOPD) that may require hospitalization, at which time negative outcomes may occur up to 30 days after discharge. Several predictors of negative outcomes have been documented.Areas covered We considered five negative outcomes related to patients hospitalized with AECOPD treatment failure, non-invasive mechanical ventilation (NIMV) failure, prolonged length of hospital stay (LHS), sho
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