https://www.selleckchem.com/pr....oducts/Sunitinib-Mal
This has allowed for the identification of interesting substates of the unbound RBD that are lower energy than the ACE2-bound conformation, and that block key residues along the ACE2 binding interface. These novel unbound substates may represent new targets for therapeutic design.Zimmerman proposed in 1966 a type of Möbius aromaticity, which involves through-space electron delocalization and has since been widely applied to explain reactivity in pericyclic reactions, but is considered being limited to transition state
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