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03, 95% C.I. 0.79 to 1.35), nor increased bleeding (5840/10906 patients, OR 0.84, 95% C.I. 0.65 to 1.08), but it was associated with higher anti-Xa levels (284/294 patients, ES 2.04, 95% C.I. 1.16 to 2.92, p0.0001). A significant heterogeneity was present for comparison of anti-Xa levels (I =94%, p=0.0001) but not for VTE occurrence or bleeding (I =7.6% and 12.8% respectivel). None of the moderators explained the heterogeneity of the results among primary studies. Weight-adjusted dose as compared to fixed-dose of heparins in the pr
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